Category Archives: Biotech Soap Opera

BioBonds for Research

Rupert hates talking to scientists. Pharmaceuticals are all about business, not science. Aren’t they? Yet here he was in his corner office cornered by two lab coats with nerds inside each. He sighed and waved them both to the one chair in the room. “Get on with it,” he said impatiently. “What did you need to discuss that our Chief Scientific Officer couldn’t handle?”

“It’s about financing our research,” said Nerd #1.

“Oh,” said Rupert. “Then you should talk to our CFO.”

“We did,” said Nerd #2. “He was so excited, he sent us here right away. It’s about how football stadiums get built.”

“Stadia,” said Nerd #1. “One stadium, two stadia.”

Nerd #2 wrote a note to himself, then said, “We want to offer research bonds as investments. There’s already a research-focused pension fund in Australia.”

Rupert grunted. “Research. Isn’t that what NIH is supposed to fund? We can’t afford to waste our money on so many dead ends. As a matter of fact, I was thinking of cutting back R&D like AstraZeneca did. I told you guys, stop doing experiments that fail! Just do the ones that work.”

Nerd #1 said, “We don’t know which will work until we try them. Think how many retirement funds and 401(k)s would buy bonds to support Alzheimer’s research…while they still can.”

Rupert swiveled his chair and stared out the window. “Hmmmm,” he said.

Source of Inspiration:    http://tinyurl.com/cn3zbqq

 

Funding Gets a Kick in the Pants

Rupert gets a call from crack(ed) fundraiser Frida de Thirteenth, who has a great idea.  “Surely you have heard of Kickstarter?” she says.  “Cappuccino Pharmaceuticals can raise money for drug development and clinical trials.”

“But Kickstarter is where people donate, not invest,” Rupert says.  “It’s enough to start up and do some limited project.  Who would just give us millions of dollars for a clinical trial?”

“Frida understands your confusion,” says Frida.  “That’s why KickPantser exists.”

“Ki – What kind of name is KickPantser?”

“KickPantser is to sustain an ongoing concern through gifts,” Frida says.  Cappuccino must donate millions to a central funding organization.  They in turn give grants for development and clinical trials.  To Cappuccino.”

“Hmmm…” Rupert ponders the idea.

Episode 29: Vivian Visits (Part 2)

“I trust you are not simply changing the subject,” Maybelle said.

“I hope I can,” said Rupert.  “I mean: No, this is quite relevant.  Indiscretions.  Alas, in this case it started with one of mine.  My one.  Indiscretion.  Yes, I was indiscrete in promoting our new Marketing Vice President.”

Vivian looked at her wrist and blinked.  “Oh,” she said as she pulled out her phone.  “I keep forgetting that I stopped wearing a watch years ago.  Anyway, will this take long?”

Rupert looked at the 18K rose gold Ulysse Nardin Marine Limited Edition chronometer on his wrist.  Maybelle examined the Omega Ladies Constellation Small Seconds Chronometer Limited Edition watch on her wrist.  They both looked at Vivian’s phone, then at each other.  Vivian looked up at them from her phone.  “What?” she asked.

Rupert cleared his throat.  “Let me tell this story since I mentioned it.”  He told them about Dr. Buttinsky’s poorly conceived therapeutic project and of Marlene’s clever and innovative presentation.  “Clearly, if she can make a garden of such muck, she could do wonders with our best products,” he said.  “So I promoted her out of the Research group to Vice President of Marketing to give her the opportunity to shine.”

Maybelle’s eyes glazed over.  “Bully for you.  Not all promotions work out.  What else is new?”

“What’s new is she treated our sales reps like cricket balls,” Rupert said.  “I didn’t find out the situation until the lawsuit was already filed.”  Maybelle and Vivian sat up abruptly.

“Sales reps?” asked Vivian.  “Isn’t Marketing separate from Sales?”

“Ah,” said Rupert.  “It seems our current Vice President of Sales recognized a rising star and latched on for the ride.”

“So two people scheming, he and she,” said Maybelle.  “What about that cricket ball?”

Rupert rested his chin on his folded hands and spoke slowly.  “It started as if he made 155 not out and she was unbeaten on 116 as they made a fifth-wicket stand of 203 to take our team to a first innings total of 570 for four declared just in time for tea.”

Vivian and Maybelle stared blankly at him.

Rupert inhaled.  “Then this disgruntled sales rep took a wicket off his first over when he bowled with a flighted delivery for 13.”

“What?” Vivian asked.  Maybelle’s mouth dropped open.

“Don’t you see?” Rupert asked.  “Our disgruntled rep struck nine fours in his 193-ball innings for his century.”

Maybelle started tugging at her hair.  “Rupert.  You know cricket makes absolutely no sense whatsoever.  And neither do you.  Tell us what happened or shut up.”

Rupert looked hurt.  “Cricket.  It’s played around the world.  It explains so much about life and…”  His voice trailed off and he looked at Vivian.  She frowned at him and glared.

“Soccer,” Rupert said.  “What about soccer?  Does anyone know what a soccer ball is?”

Vivian and Maybelle relaxed.  “Yes,” Maybelle said, “we know what a soccer ball is.  It’s round.”

Rupert held up a finger.  “Yes,” he said.  “Now what if you were treated like one?”

“Kicked around, you mean?” asked Vivian.

Rupert spread his arms wide.  “Yes, exactly.  So my two rising genius VPs started treating the reps like soccer balls.  You know.  A soccer ball just sits there until you haul off and kick it.”  His eyes passed between his two intent listeners.  “And after a while, the ball stops rolling.  So you kick it again.  If it goes flat, get a new soccer ball.”

“That’s it, is it?” asked Vivian.  “That’s the analogy?”

“Um.  Yes.  That’s the – that’s the analogy.”

“Oh.  Ha ha ha, how witty,” Vivian said with a totally deadpan expression.  “Sounds like Management having an average day.”

“Apparently Marlene felt free to download all sorts of studies off the Internet, and insisted the sales reps do likewise.  That means for FDA-approved uses.”  He paused.  “And any off-label things some researcher somewhere might care to try.  The Sales VP, a guy named Billy Smiler, thought this was a good idea.”

“I do, too,” said Vivian.  “But I assume it doesn’t work that way in pharma.”

“No, there are all sorts of regulations about sales rep behavior,” Rupert said.  “They can give clients only the sanctioned studies that discuss approved uses for drugs.  Never off-label stuff.”

“You said that you lifted her from Research,” Maybelle said.  “So of course you explained the new legal requirements for her new department, right?”  Rupert raised his hand to his mouth but stayed silent.  Maybelle continued, “Or she had years of experience in Sales somewhere else?”

“Um,” said Rupert.  “She came up with clever marketing phrases.”  He looked down at the floor.

“Clever.  Clever marketing phrases,” Maybelle said.  “And this Billy Smiler, the guy actually responsible for the sales team, he just let all this slide past?”

“Oh, no, not at all,” said Rupert.  “He actively encouraged it.”

“Okay, so they downloaded stuff off the Internet,” Vivian said.  “Anyone could do that.  Anything else?”

“Well, Billy hired newbies, people who had never sold anything to anyone before,” Rupert said.  “The lawsuit claims any sales rep with real experience would know the partying was unethical.”

“What partying?” Maybelle asked.  “Were you at any of those?”

Rupert blinked.  “Me?  No one ever invited me to – no, I was never involved in this stuff.”  He looked at his hands.  “Too bad, some really nice restaurants.  Each rep had a quarter million to spend per year on medical education programs.  Apparently the only education doctors got was that food is good medicine.  Especially dessert and wine.”

Maybelle clapped her hands together with a gunshot report.  “Aren’t there states with laws against goodies to doctors?”

Rupert gave a wide-eyed stare of feigned wisdom.  “Ah, but they let you bring meals to the doctor’s office.  So just ask for meals to go.  They go from kitchen to table, maybe twenty feet away.  Spending too much per doctor according to state laws?  Claim another hundred doctors stopped by.”  He rolled his eyes and looked out the window towards the Pacific Ocean.  “Then there was the guest speaker they brought in to talk about how doctors could increase reimbursements while avoiding jail time.  Oh, just Google ‘increase revenue decrease jail time’ and see.”

Vivian lifted her phone and poked at it.  After a few seconds, she said, “Oh, my.”

“And the golf and hunting trips,” Rupert said.

“Okay, dear, we get the picture,” Maybelle said.

“And the honey-baked hams and bottles of wine.”

“Alright, dear.”  Maybelle looked at her watch.  “It’s frightfully boring and repetitious.  I’m sure you’ll tell us about tickets to basketball games and such.”

Rupert looked up in surprise.  “How did you know?”  He looked down again.  “It gets worse.  I just heard our defense lawyers took it upon themselves to try a new line of questioning the plaintiffs.  It’s right there from the Superior Court of New Jersey.  If you Google ‘deposition anal sex catholic mass,’ you’ll see what I mean.”

Vivian gasped.  Maybelle said, “Anal se – Rupert!”

Rupert clutched his head.  “I know, I know.  It almost worked for a Big Pharma company, someone thought it might work for us.”  He pictured himself sitting in his office clutching the phone and saying, “It’s a crazy idea but it just might work.”

“Apparently there was a party for sales reps,” Rupert said.  “I wasn’t invited.  There was a hotel swimming pool involved.  It seems tuxedos and swimming pools are a bad mix.  Add in vodka shots and people throwing dishes out the window and burning the drapes in the fireplace.  This Billy Smiler put the moves on some of the reps, groping and grabbing.”  Rupert looked up.  “He told the rep that’s the way it is at Cappuccino, and she’d better get used to it.”  He clutched his head and groaned.  “Sales tripled that year.  But.  But.  We need a whole new Sales department.”

“So was this Marlene of yours involved?” Maybelle asked, still waving the riding crop.

Rupert looked up.  “Marlene.  Ah.  Yes.  She and this Billy, they um.”  He paused, then went on.  “There was a convention, some international conference.  She and Billy had a doctors’ presentation over a dinner in some fancy restaurant.  Then, after midnight, they went to some loud party bar with a live band.  Some other doctors were there and watched these two get drunk.  Marlene got on stage with the band and danced until they tossed her out of the bar.”  Rupert shook his head.  “In front of all those docs.

Vivian rolled her eyes and lifted her phone.  “Let me guess.  I just Google “vodka shots bar dancing” and I’ll find it made headlines.”

Rupert clutched his head in his hands.  “Then there was a contract clinical researcher somewhere in the U.K. working on one of our drugs, to show if it was worth doing a clinical trial.  Turns out he diddled with the data so it looked like some animal experiment worked when it had failed.”  He let out a moan.  “This guy was one of the first people to be caught violating the U.K.’s Good Laboratory Practice law.”  Rupert looked up.  “At least he wasn’t the first!  Someone in Scotland beat him to it, screwing up a Roche study and maybe lots more.”

“People crack under the pressure, dear,” Maybelle said.

“Yes, that’s what causes indiscretions,” said Rupert.  “I think I’m cracking.  Bad choice in promoting someone, and bad luck.  I need better luck.”

As he said this, he noticed that Vivian had frozen with a look of terror.  He heard the roar of a helicopter as it passed overhead and flew away.

Rupert said, “Helicopter,” and thought again of the National Guard helicopter that buzzed his apartment in Silverlake.

“Helicopter,” said Vivian as she thought again of her jealous ex-boyfriend.

“Helicopter,” said Maybelle as she thought again of the helicopter that buzzed the MadaShack.  “Well.  It’s gone now.  And I must go, too.”

Maybelle reassured Vivian that her consultations would find a way to raise funds for Vivian’s enterprise.  Maybelle looked over at Rupert.  “I do know at least one sugar daddy who will be glad to invest.”

The squawkbox in the hallway beeped and a voice said, “Good day, Mr. Madasheck, I’m here to exchange your out-of-fashion automotive device with your new Lamborghini Veneno.”

Rupert turned to the squawkbox interruption and said, “Nonsense, there were only three of those made.  Four million bucks and only 750 horsepower.  Where’s my Ferrari?”

“Ha ha, that is our little joke.  Yes I have your Ferrari LaFerrari.  Seven hundred forty-nine horsepower waiting for your command.  And of course only one million, er, bucks.  You could buy two more for the price of our competitor.”

Rupert stood up and edged past Maybelle.  “Yes, I’m sure we can arrange something to help Ms. – um, Ms. Spitfire here attain her goals,” he said.  “Now I really must meet this gentleman to see about exchanging the Tesla.”

Maybelle’s eyes widened.  “I thought you liked that car.”

“I do,” said Rupert.  “But I may be a customer of Elon Musk’s other company.”

Vivian asked, “What other company?  Isn’t one exotic car company enough?”

Rupert sighed.  “Oh, not at all.  Nothing is ever enough.  He is also CEO of Space Exploration Technologies. Musk plans to start a Mars colony by selling 80,000 tickets for $500,000 a shot.  So I bought the LaFerrari and still have enough left over to afford Mars.”

“Oh?” Maybelle asked.  “Were you planning to send me on a one-way trip, or try to escape yourself?”

 “Maybe Musk plans to set up solar panels on Mars as recharging stations for his Teslas,” Vivian said.  “The ones he’ll sell on Mars at the planet’s only car dealership.”

 “This could be the way people on Earth cash in and get out,” Rupert said.  “Martian law is whatever the first colonists say it is.  It could be Ayn Rand’s Galt’s Gulch.”  He paused and scratched his chin.  “Or it could be the prison for people too powerful to prosecute.”

Rupert eased out of the room and towards the door to the garage.  Vivian got up and strode to intercept him in the kitchen.  He turned to meet her gaze as she stood silently.  Her hands clenched and unclenched as she blinked back tears.

 “Alright already,” Rupert said.  “Why is it I never heard from you for all this time?  Why did you come now?”

“I’ve been busy,” Vivian said as she stared at her shoes.

“Busy,” Rupert said.  “Busy doing what?”

Vivian sighed and looked straight at him.  “Busy giving birth.”

Stay tuned to find out next time:

  • Does Vivian really carry Rupert’s love child?

  • Will Vivian get a genetic profile done?  Or did she already?

  • Will Rupert wish he were on Mars very very soon?

  • Will pharmaceutical reps ever stop trying to circumvent the rules against bribing doctors to prescribe certain drugs?

  • And what about that pesky helicopter?

Episode 28: Vivian Visits (Part 1)

I don’t want to do this,” Vivian Spitfire thought as she leaned out of her Beetle Cabriolet 50s Edition and her finger reached for the CALL button.  Her mind reeled from the spinning thoughts of looming unemployment, her jealous ex-boyfriend with a mean streak, her own horror, and the medical crises that swept over her.

She felt very small in this Malibu enclave filled with rich people suing each other over everything and nothing.  Her eyes swept up to the wrought iron fence ten feet ahead with its sign that proclaimed ‘MadaShack’ and barred her way.  A gentle voice said, “Speak, friend.”

Vivian leaned towards the speaker and said, “Hi, I’m Vivian, here to see Maybelle Madasheck?”  The gates of the iron fence swung towards her with a soft whisper.  She drove into the circular courtyard and around the bubbling fountain to the large double doors of iron-banded oak.  The gates swung shut, cutting off her urge to flee.  She half expected to see a liveried servant appear to open her car door, but the courtyard remained silent.  “Well,” she thought, “it’s showtime.”  She inhaled, put on a pair of glasses, and stepped out of the car.

Minutes later, she sat in the Madashecks’ drawing room and wondered how anyone could draw there.  She saw no desks or tables, and it looked like no place for an artist to wield a brush.  The furniture resembled a museum display, yet she set off no alarms as she sat on a delicate antique from another continent and another century.  Still, she feared that any movement would cause the flimsy construction to splinter and drop her to the thick Persian carpet.

Maybelle sat in a much sturdier overstuffed Morris chair, breathing hard.  “I must say, you did give me a shock, my dear.  I am not at all sure from where, but I have indeed seen you before.”  She looked over Vivian’s shoulder to her own computer screen in the next room.  Vivian’s face bounced gently around the screen.  She thought of Vivian’s other face bouncing around Rupert’s computer screen in his own separate office.  “How did those screensavers get there?” she wondered.

“I know Rupert,” Vivian said, “but I do not think we’ve met before.  I started my own software company but I’ve almost run through my own funds.”  She thought of the box of Me&Ro 18 karat gold Indian diamond drop earrings that Rupert gave her long ago.[1]  “Now I need more funding so…I visited.  I was recommended to your consulting firm, called for an appointment, and here I am.”

Maybelle said, “We have some time before Rupert sneaks in.  He drives a Tesla so he will just suddenly appear at any moment.  So tell me what brings you here.  I believe I suspect, but I’d rather hear your story than speculate.”

“Do you suspect?” Vivian asked.  She lifted her glasses, then dropped them back on her nose.  “Ah, it must be the blue blood.  Oh, there it is, some red heat.”

Maybelle felt color rising up her cheeks.  “What do you mean?  What red heat?”

Vivian took off her glasses and held them up.  “These render the world as a heat map.  Cooler temperatures are blue, and hot things are red.”

Maybelle sat back in her chair and crossed her arms.  “I’m sure that’s very clever, my dear.  Is this your invention that you want to sell?  Do you need my advice on marketing?  All well and good, but what is this business about Rupert?  He knows nothing about marketing.”

Vivian pulled a glasses case out and held it for Maybelle.  “If you watch the human face, you see the same thing.  Normally blue and green for calm and collected people.”

“Oh, well, that’s different,” Maybelle said.  “A cute party trick.”

“And red as people flush.  You know, when they lie.”

Maybelle froze.  “Could.  Could I.  Could I borrow a pair?  I might have a use for these.”

Vivian relaxed.  “Yes, I’m sure you might.”

**

“Hooray, I made it home without the car running out of juice,” Rupert said as he came through the kitchen door from the garage.  “I think the secret is not to drive a Tesla in a blizzard.  The New York Times and Tesla’s executives should keep that in mind next time they want to get into an argument about car performance.  Is the housekeeper here?  I saw some kind of car in the courtyard.”

As Rupert stepped into the drawing room, his face lit up.  “Vivian,” he said with scarce-concealed joy.  “I never thought I’d see you again.”  He broke off when he realized that Maybelle sat in a chair by the door.  She had a long riding crop in her hand, and she sat between him and the only exit.

“Rupert,” Maybelle said, “do join us.  I was just having a chat with Ms. Spitfire here.  A delightful woman of business.  She tells me that she admires you as a man of business.”  She smiled.  Rupert smiled.  “Monkey business.”  She smiled.  Rupert didn’t.

“I must recommend my new optometrist to all my friends,” Maybelle said as she turned to Vivian.  “I can see so well in the…heat of the moment.”  She turned back to Rupert.  “Ms. Spitfire has some matters of business, some questions to ask you.”

“Who’s my mother?” Vivian asked.

Rupert said, “Why, Eimagoinne Comatosa, of course.  Now she calls herself Emma.  Just Emma.”  He blinked twice.  “Yes, I knew her so long ago.  Why do you ask?”  He looked at Maybelle and her riding crop.

“And who is my father?”

Rupert stuttered and stared at his hands, then looked at the doorway and at Maybelle’s riding crop.  His eyes flickered towards the window, then back at his hands.  “Um,” he said.

Maybelle looked at the riding crop she held tightly.  “You used to like this.  Very much.  Does it bother you now?”

Rupert narrowed his eyes.  “Are you threatening me with that stick?  Why?”

Maybelle petted the riding crop gently.  “Threaten?  No, no.  I’d love to tell our guest how much you like this.  Shall I?  Or can you tell us who is Vivian’s father?  Perhaps there was some ‘youthful indiscretion’ involved, hmm?”

“Um, yes,” Rupert said.  “Youthful indiscretions were made.  As they have been and always will be.  It’s the human condition.”

Maybelle and Vivian gazed at Rupert for a moment.  “Ah, Mr. Blue-blood, admit nothing,” said Maybelle.  “Have any indiscretions been made lately?”  Rupert began to turn red, but did not answer.  Maybelle asked, “Would any indiscretions involve Vivian here?”

Rupert turned so red that the heatmap glasses nearly burned out. “I didn’t know we were related!” he shouted.

“So,” Maybelle said, “there were some indiscretions, Mr. Redface?”

Rupert’s face went blank.  “Redface?” he asked.  Silence.  “Mr. Redface?  Is that the father who wouldn’t go to Canada with you during one particular Spring Break?”

Maybelle gasped.  “No.  He was Mr. Redfern. Horace Redfe-”  She clapped a hand over her mouth.

Rupert glared at her and went on. “How about the Aussies who serenaded you with a song they called ‘Bouncing Matilda’?  Shall I sing it for us?”

Maybelle made some strange vocal noises, then popped something into her mouth.  She looked up and saw both Rupert and Vivian staring at her.  “It’s my. It’s medi-meh-medicine,” she said.  “Called Sirna ShuttheFoxup.”

There was a pause of silence and Rupert blinked.  “Called what?” he asked.  “Fox as in shut up Fox Ne-”

“Fox as in Foxp2 protein,” Vivian said.  “Don’t you keep up with the news?  Foxp2 is the language protein.  Shut down production and you become less talkative.”

Maybelle turned bright red.  “I believe it helps me not say regrettable things.”  She held up a capsule.  “This is filled with nanny particles.”

“Nanoparticles,” Vivian said.  “It beats the original work, needle injections into the brain.”

“Ugh.”  Rupert scratched his head and spoke carefully, a word or two at a time.  “So, if you stop this, um, Foxp2, you don’t talk as much.  Can you turn it up?”

Vivian looked at him warily.  “Yes, you can take Sirna FoxPlease for the opposite effect.  Why?”

Rupert squinted and looked around the room.  “Does the CIA know about this?”

Maybelle roared.  “The CIA or somebody knows about this.”  She held up a large photo of Rupert and Vivian sitting on a balcony.  “Tell me more about these not-so-youthful indiscretions.”

Rupert said, “Helicopter,” and thought of the National Guard helicopter that buzzed his apartment in Silverlake.  His not-so-secret apartment.

“Helicopter,” said Vivian as she thought of her jealous ex-boyfriend.

“Helicopter,” said Maybelle as she thought of the helicopter that buzzed the MadaShack during the Malibu Fire/Mudslide/Earthquake.[2]

“It might seem indiscrete, but I was getting re-acquainted with my long-lost daughter,” Rupert said. “Nothing more.”

“Nothing more, Pinocchio?” Maybelle asked.  “I believe I’m seeing red.”

“Certainly nothing more than your own visit with that Horrible Redface guy who popped up again not so long ago,” Rupert said.

Rupert did not need heatmap glasses to see Maybelle turn red.  She said, “Horace Redfern stopped by to apologize for his own indiscretions back in our college days.”

Vivian saw two very bright red people through her glasses.  “Well, I call it a draw here,” she said.  “I see indiscretions on everyone’s part.”

“Well, they were long ago and they weren’t as bad as our recent Marketing department debacle.  I had to sack the whole lot of them.”  He slumped into a chair and muttered.  “Alcohol does strange things to people’s judgment.  And vodka seems to be the worst.”

Stay tuned for Part 2 of Vivian Visits, coming soon!


[1] See Episode 4 of the Rupert Files.

[2] Episode 4 of the Rupert Files.

Episode 27: Helping Grandpa Get It Up

Betty Lidalot locked her office door and brought up the latest breast cancer awareness app and watched as a parade of shirtless muscled hunks reminded her to give herself lots of TLC:  Touch, Look, and Check.  She dreamed of help by Luke, Anthony, Keith, Jerald, Jesse, Leon … and Rupert Madasheck.

She broke off the daydream.  ‘Rupert is married,’ she reminded herself.  ‘I may as well dream of Yehud Shuar, may he rest in peace.’  She fended off the memory of Yehud’s death from brain cancer.  ‘TLC does not work on brain cancer,’ she thought.  ‘Well, it’s time to see what Cappuccino Pharmaceuticals is up to.’  She opened a desk drawer and pulled out a gift-wrapped box with an envelope inscribed, ‘To Rupert.’

An hour later, Betty ushered herself into Rupert’s empty office.  After a minute, Rupert stumbled in without noticing her.  He blundered into his desk, banged his knee into its solid oak, and dropped into his chair.

“Something wrong?” Betty asked.  “I-”

Rupert jumped with a strangled cry and swiveled his chair around.  “Oh.  Betty.  I didn’t see you there, I’m sorry.”  He sat up and straightened his tie.  “I’ve been worried about something.  Things.  Some things.  Ack.”  He noticed the wrapped box in Betty’s hands.

“Something for you,” she said as she handed him the box.  “I found something special.  So special that I plan to present it at a Women in Business event in San Francisco.”

Rupert turned the box end over end and noticed the wrapping paper said, ‘Barry Callebaut – Chocolate to Raise Your Spirits.’  “I never heard of this Barry stuff,” he said.  “Some new kid on the chocolate block?”

Betty smiled.  “It’s the world’s largest chocolate supplier in the world,” Betty said.  “They sell to all the companies you’ve ever heard of, and now they decided to branch out on their own.  But tell me.  What are these things that have you frantic?”

Rupert stared at the box in his hands.  “Well, one is that I must send something to Maybelle for Valentine’s Day.  It’s not just an option, it’s life or death.”  He looked up at Betty.  “I hate to ask, but could I -”

“Certainly not.”  Betty glowered across Rupert’s desk at him.  “It simply will not do.  Get her a box of See’s or something.  These are, well, special.  You’ll appreciate them more than she will.”

Rupert raised his eyebrows.  “Oh?  Liqueur or whiskey filled?”

Betty glanced up at the ceiling.  “Oh yourself.  You just enjoy them.  After you tell me what the other thing is.  Or are there more than one?”

Rupert sighed.  “Just one at the moment.  It’s an opportunity more than a problem.  We need to take advantage of it and I’m not yet convinced our veepard is up to it.”

“Veepard?” Betty asked.

“VP of R and D,” Rupert said. “We are on our fifth in four years.  But we need to move.  Questcor entered the snake oil business years ago, and we didn’t even notice.”

Betty laughed.  “Oh, Rupert, I thought you had something serious on your mind.

“Let me tell you, Maybelle is deadly serious now.  But about Questcor.”  Rupert leaned back in the padded hydraulic chair and glanced at the holes in the acoustic ceiling tiles.  “They acquired an anti-inflammatory drug that was approved in 1952.  Way before we were born.”  He pulled a small vial out of his pocket.  “This gel was sold for some rare syndrome.  Then they sold it at $50 a pop for gout.  Until 2007.”

After three seconds of silence, Betty inhaled.  “Am I supposed to guess the new price?”  Rupert smiled and stared at the ceiling.  “OK,” Betty said, “five hundred dollars.”

Rupert sat up and stared at her round dilated pupils.  “Twenty.  Three.  Thousand.  Dollars.  And it’s even more these days.”

“What I understand,” he continued, “is that it’s now marketed for multiple sclerosis, some kidney problem called nephrotic syndrome, and some rheumatology problems.  The original claims covered about fifty diseases.   Remember, it was approved back in 1952.  Back then, the FDA didn’t even need clinical trials.”

Betty’s eyes went wide with comprehension.  “Oh.  What other drugs are out there from back then?”

Rupert sat up.  “I’m having people sift through the records.  Just think.  You can claim anything you want and you never have to prove a thing.  Stuff that old gets grandfathered in.”

Betty frowned.  “Except us.”

“You could be grandmothered in,” Rupert said, “but you still need to wait a few decades.”  Betty blushed, and Rupert smiled.  “Ah,” he said, “but you do ask the key question.  What grandfathered drugs can we acquire so we can claim all sorts of stuff without the bother and expense of clinical trials?”  Rupert stood up and began pacing around his office.  “Opportunity.  To grab it, we need to rush.”

Betty stood up.  “I need to rush, so I will leave you to ponder that.”

Rupert stopped pacing.  “Sorry. Oh, and thanks.”  He glanced at the box on his desk.  “Thanks for the mysterious chocolates.  Maybe they will help me think.”

“They will help in the way all men think, yes,” Betty said.  “That’s a fair advertizing claim.”  She walked backwards out of the office and closed the door on him.  “I’ll check on your thoughts later,” she said to his nameplate on the door.

On the other side of the door, Rupert stopped pacing and opened the envelope taped to the box.  He read the card inscription: ‘Business partners for now.  Valentines forever!  XXXX, Betty.’  He sat down.  After a pause, he opened the wrapping paper to find a handsome box with the Barry Callebaut logo prominently displayed.  He thought of his diet.  He pondered his lack of exercise.  He opened the box, pushed some kind of pamphlet out of his way, and ate two chocolates.

As he rolled the pair of chocolates across his tongue, he looked at the discarded pamphlet.  Instead of the expected pictogram of each chocolate’s flavored filling, it looked more like a medical prescription package insert with lots of tiny print.  “Would Betty pull a mean trick on me?” he wondered as he began reading.  In between interrupting thoughts of Maybelle and snake oil, Rupert noticed the name of the European Food Safety Authority.  “So this won’t kill me?” he thought.  “That’s good.”

The large print read, “European Food Safety Authority validates the Barry Callebaut claim that their cocoa enhances blood flow.”  Rupert looked up in surprise.  What on earth does that mean? he wondered as he popped a third chocolate into his mouth.  He pulled his guyPad out, brought up its phone app, and called Betty.

Her face smiled from the screen, with a taxi view in the background.  “Rupert!  Sorry I had to run.  Did you try the chocolate?”

“Of course, I couldn’t resist,” he said.  “Should I stop at three, or can I have a fourth?”

Betty gasped.  “Oh, Rupert, they recommend you have one a day and never more than two.”

“What?” he asked.  “Where does it say that?”  He flipped through the package insert.  “What is this?  Not what I usually find in candy boxes.”

“It’s their report validating the claim that the natural flavanols in the cocoa enhance blood flow.”

“Blood flow?  That doesn’t sound appealing in a chocolate,” Rupert said.

Betty closed her eyes.  “Rupert.  Do you know how Viagra works?”

Rupert’s guyPad hit the floor.

____

Twenty minutes later, Marlene strutted her six foot four frame through Rupert’s office door atop her Sam Edelman Lace Up Platform Booties with five inch heels and stopped dead.  Rupert’s ceiling-to-floor window jumped at her with a swirl of motion.  It showed a rotating panoramic landscape taken from Dubai’s Burj Khalifa building, taken by Gerald Donovan. Skyscrapers, empty lots, construction sites, and islands in the shape of palm fronds all arced across the giant screen.

As Marlene tottered with dizziness, Rupert rushed around the edge of his desk.  She swayed precariously, but he swept past her to shut his office door.  Then just as she crashed floorward, she felt herself become weightless except a slight pressure against her waist and her knees.  Rupert’s arms cradled her, but then she felt a third pressure.  On her hip.

Rupert set her back up on her platform boots.  “Does the view bother you?  I find it exhilarating.  But I can turn it off.”  The room plunged into darkness.

“Did you really call me here to discuss Dr. Buttinsky?” Marlene asked as she waited for her eyes to adjust.

“Oh, let’s hope he doesn’t butt in,” said Rupert.  “I wonder if he is at all competent in our hour of need.  At least you plan.  You prepare.  You think.”

“And thinking is the new sexy,” Marlene said.  Her dilating eyes made out the image of Rupert wearing nothing but three socks.  She tried not to stare at that third sock.

“Have a chocolate?” Rupert asked.

Episode 26: The Shinola Cure

“So remind me,” said Rupert. “Why is the FDA raising a stink about our new therapeutic transplantation program?”

“Because we propose transplanting fecal matter into patients,” said Dr. Buttinsky.

Rupert’s response rudely sent his coffee across the conference table. He mopped up the mess with rapid dabs of a tissue while several others in the room ran for paper towels. Rupert grabbed a towel and pressed it to his face. His muffled voice said, “Doctor, do not ever tell me something like that while I sip coffee. Or anything else.”

Dr. Buttinsky pulled his face in and looked around the room. “Something like what?” he asked. His eyebrows were raised in a startled expression as if he had his third facelift just that morning.

Rupert stared at him. “You’ve been our veepard for a month now and you have no clue?”

“Veepard?” Dr. Buttinsky asked.

“VP of R and D,” Dr. Horrible said. “You are our fifth in four years. Don’t make us regret hiring you.”

Rupert looked at his hands and pulled his shoulders back. “As Chief Science Officer here, I expect Dr. Horrible to know exactly what is going on.” Rupert paused and looked at the seven scientists at the table. “Yet Dr. Horrible could not tell me what you are proposing here.”

“Marlene?” said Dr. Buttinsky as he looked at a young woman at the table. She poked at her computer and said, “We plan to make curing C. difficile easy.”

“Marlene,” Rupert said, “you should be in marketing. That’s good, very good.”

The projector switched on and a bright patch of light proclaimed, “Difficulties with difficile? Shoo it away with the Shinola cure!”

Marlene stood up. And up. And more up, towering above the table. “Several Canadian groups have been studying fecal transplants from healthy patients into people with persistent C. difficile infections. These are people suffering for years and who do not respond to antibiotics. We can cure them within one or two days.”

“Well, that’s a pretty tall order,” Rupert said. He clapped his hands over his mouth. “Sorry.”

Marlene rolled her eyes, then changed the projector display. Rupert read “Clinical Trials” and “The ‘Ick’ Factor.” Marlene said, “We are all aware this sounds most unpleasant, and cannot imagine how difficult it is to recruit patients for clinical trials. We must convince the FDA of safety and efficacy. But why is patient recruitment so difficult?”

“Because no one wants someone else’s poop put in them,” Rupert said. “You’ll never get anywhere with this.”

Marlene smiled and straightened up another few inches. “Wrong. All the patients want the treatment. None of them want to be the Control arm with standard antibiotics treatment only.”

Dr. Buttinsky said, “The disease is that bad. People will do almost anything for a cure.”

Rupert’s eyes glowed. “And pay almost anything? We can charge big bucks to sell them sh-”

“Shinola,” corrected Marlene.

“Wasn’t there some old saying about Shinola?” Rupert asked. “It used to be some shoe polish or something, wasn’t it?”

Dr. Buttinsky flipped through his notes and pointed at one page. “Someone recently revived the name. They trademarked all sorts of things including shoe polish and cosmetics. And wine.”

“But not therapeutic treatments,” Marlene said. She sat down and smiled across the table at Rupert. “It’s a natural.”

“Yes,” said Rupert. “I know a natural when I see one.”

Other scientists presented slide after slide of data, charts, tables, and diagrams until they heard Rupert snore. His head bobbed sideways and he sat up with a jolt. “I’m on it!” he shouted. “Yes, I’m – I…”

“So you have no objections to us proceeding with development?” Dr. Buttinsky asked.

Rupert shook his head. “I wasn’t sleeping, I was pondering.” He drummed his fingers on the table and looked at Dr. Horrible. “Come on, Dr. H, what is the obvious question here?”

Dr. Horrible glanced at his notes and said, “Two questions. First, if the data you showed are so compelling, who is our competition?”

“Just about any hospital can generate their own, um, transplantation material,” Dr. Buttinsky said. “What they can’t offer is, um.”

“Quality control and consistency of product,” Marlene said.

“What about quality control and consistency of product?” Dr. Horrible asked.

Dr. Buttinsky said, “There are researchers in Canada who are cultivating a simulated fecal product. That eliminates – sorry – the problem of screening donors for diseases.”

“Do you realize there are thousands of bacterial species in the human gut?” asked Dr. Horrible. “Which ones will you use?

“Um,” said Dr. Buttinsky.

“I took care of that,” Marlene said. “Besides contacting the original researcher, we can matrix out the likely candidates.”

Dr. Horrible turned away from Dr. Buttinsky and faced Marlene. “Very good. Any final questions, Rupert?”

Rupert’s face was very pale. “Isn’t there some more palatable way of delivering the, um, you know?”

“Well, as you saw from slide number 74, it’s usually a pint of donor material piped down the nose right into the patient’s intestine.”

Rupert’s face changed from pale to green. “Urgh,” he said.

“Researchers are interested in partnering for a freeze-dried capsule delivery,” Marlene said. “No losing anyone’s appetite, no mess.”

“Where can we work on that?” Rupert asked. “I wouldn’t want that research lab anywhere near our other facilities.”

There were unprofessional snorts of laughter from around the table. “He said ‘facilities’,” said one junior scientist.

Marlene did not so much as smirk. “There is a company called InnuEndo Solutions that is closing a research facility on Long Island. They plan to lay off everyone there, so we can have an instant workforce with incentive to deal with the less savory parts of this project.”

The research team stood to leave, Marlene towering above the others by almost a foot. As she left the room, Rupert noticed her shoes must have had at least eight-inch heels.

Later, in Rupert’s office, he saw that in bare feet she was still a foot taller than he.

Episode 25: Elevator Pitch Goes Foul

As a CEO in the Candybar Building, Rupert Madasheck had privileged access to the secret Executive’s Elevator. He stepped inside the elevator car and noticed on its display that one other exec would join him. He poured himself a glass of 1995 Araujo cabernet from the cache and settled into his favorite stuffed chair. Glancing at the keypad on the chair’s arm, he entered his floor number.

As he swirled and sipped his wine, the door opened and an elderly gentleman stepped in. The new arrival opened the 15th Century globe and poured himself a snifter of brandy. To Rupert’s surprise, the man gulped the brandy and poured more. Shutting the globe, the man sat down and entered his own floor number.

Rupert spoke first. “Rupert Madasheck, Cappuccino Pharmaceuticals.”

The other man raised his eyebrows and said, “Gary Cortescu, Pfuztercluck Pharmaceutics. Glad to share a ride with you.” The elevator began to move with a barely perceptible bump.

Gary inhaled the aroma of the brandy with a studied sniff, eyes closed. “Ah, delightful. I hate rushing these things.”

“But you did,” Rupert said. “We’re here to relax for a while, aren’t we?”

Gary sighed heavily and sipped. “Oh, yes, of course. I haven’t belted down a shot since the last disaster. Doubtless you’ve heard the news.”

“Your donations to the Heartless Institute? I won’t feign total ignorance.”

Gary sighed again. Is he going to do that a lot? Rupert wondered.

The elevator hummed softly and the walls glowed and pulsed with warm swirls of color. Gary stared at his glass and sighed again. Finally he said, “I suppose it’s my own fault. We did want to make some corporate charitable donations and I was willing to overlook some of their more controversial positions.”

“They believe global warming is a hoax, as I recall,” Rupert said.

“Well, of course it is. But that is irrelevant to us. Let the energy sector worry about that. Our industry has its own issues.”

“Don’t they oppose evolution to the point that they think bacteria don’t evolve?” Rupert asked.

“Oh. Um, well, yes. But leave that to the education sector to worry about.”

“Remind me how they explain bugs mutating around antibiotics.”

Gary rubbed his chin. “I believe it’s cosmic rays according to one statement.”

“Which don’t exist, according to another.” Rupert sipped his wine and recalled a recent news flap. “Didn’t they declare that the Higgs Boson was also based on junk science?”

Gary chugged the rest of his brandy and coughed. “I’d almost forgotten that. But again, education sector. Not my department.” He stood up shakily and moved back to the globe. “Let us not dwell on these things. We are here to relax for a brief moment on our rush through an unrelentingly hostile world, are we not?”

Rupert sipped his wine and let the taste linger. He wished the elevator would never arrive at his floor. Yet he could not let go of the topic without asking. “But why did Pfuztercluck donate to the Heartless Institute at all?”

“Like any sensible business, we agree with their push to eliminate price controls and reduce regulation.”

“You know that they also want to eliminate corporate subsidies,” Rupert said. “Wouldn’t that include research grants?”

Gary looked thoughtful. “I’m not sure we need research grants, do we? That’s for the small companies. Our competition, so to speak.”

Rupert set his glass down and leaned forward. “We often rely on those small companies to invent. Then we license what looks promising. I don’t understand why, but the startups are where innovation happens. So isn’t Heartless working against your own interests?”

Gary sat down and delicately sipped his third snifter of brandy. “Ah, my lad, you are young indeed. We support only the one advocacy arm of theirs that supports us.”

“Of course, of course.” Rupert took another leisurely sip. “But what is that?”

“Why of course they believe that all FDA rejections are based on junk science. Now, outside this elevator I could never admit that we support their ‘Freedom to Pick Your Meds’ initiative.” Gary leaned back in his chair and sighed yet again. “Ah, what a world it would be if people could decide what medicine worked for them without any government stooges getting in the way.”

Rupert was aghast. “Are you suggesting we do away with the FDA altogether?”

Gary closed his eyes and smiled. “Ah, you may say I’m a dreamer…” His voice trailed off. Rupert sipped his wine. The elevator hummed softly and the colors swirled.

The door opened and they both looked up. “Good to meet you, Gary. This is my floor.” Rupert put his glass in the collection grip and walked out to the hallway and his day’s destiny.

That evening, Betty and Rupert met at a single malt tasting room and chose suitably snooty single malts. Betty said, “I got a letter addressed to the Chair of Cappuccino Pharmaceuticals today.”

Rupert said, “That would be fitting since you are indeed the Board Chair.”

“It was from a group of investors concerned about contributions to one entity known as the Heartless Institute. What do you know about them?”

Rupert downed his single malt in one gulp and gasped for breath. “Never heard of them.”

Copyright ©2013 Bixogen, Inc. All rights reserved. Used by permission.
No part of this work may be reproduced or transmitted in any form or by any process without prior written permission. Continue reading

Episode 24: From P to Z

Betty sat in her office working on the evaluation report for prospective client BaryNucular Pharmaceuticals when she heard a strange chirping noise.  After a few chirps, she realized it was the rarely used landline.  “Who would be calling me on that old relic?  Good thing I have a SilenTouch keyboard,” she thought.  “I need to get this report done.”  Her fingers danced on the keyboard as she answered with the hands-free set.  “Betty Batter Buxholme and Bucolix,” she said.  “This is Betty.”

The high-pitched whiny voice of Beekman Byrdkowski replied, “Hi, Betty, how are you?”

“Beeky Byrd,” Betty chirped.  “How are you these days?  Any new schemes for success?”  Her fingers paused, then continued to dab and poke at the keyboard.

“Doubtless you heard about the Chinese lab that turns urine into brain cells?” Beeky said.  “It was in Scientific American so you know it must be true.  First, they isolate kidney cells out of urine.  In less than two weeks, they can grow stem cells.  In four weeks, they can turn these into neurons.”

Betty stopped typing.  “That’s amazing.  Are you thinking of gearing up a program to study neurogenetic diseases or autism spectrum disorders?  Beeky, that could be huge.”  She briefly thought about all of Beeky’s previous schemes as he sought her help in raising capital.  “For once, I think you have a medically valid concept,” she said.

Beeky’s chuckle clucked in her ear.  “Oh, I can’t be that ambitious all at once,” he said.  “I have a plan for generating food for zombies.”

Betty laughed.  “Zombies, indeed.  Yes, I see, grow and harvest brain cells to keep your army of zombies fed.”

“Well, actually, you poison the cells and leave them outside to kill rampaging zombie mobs,” Beeky said.

“Ha ha,” said Betty.  “Very witty.  Now seriously, what can I do for you today?”

Beeky inhaled deeply and sighed.  “Raise about twenty million for development, sterile bottle and filling, and marketing under the name ‘Zombie Zapper.’ There are ten zombie movies slated for release in 2013.  We need to get ready.”

“Ten movies?” asked Betty.  “Says who?”

Beeky sniffed.  “Surely you keep tabs on the Zombie Zone News?  IMDb lists twelve for 2013 release in the US, plus two more in 2014.”  Beeky’s voice began to climb in pitch and urgency.  “This will be huge, much bigger than global warming or the economy.  This is about life as we know it.”

Betty rolled her eyes, glad that it was not a video conferencing call.  “Beeky, we invest in biotech.  You are talking entertainment, not our field at all.”

“Entertainment?  You call rampaging hordes of zombies entertainment?”  Beeky choked as he gasped for breath.

“It’s movie tie-ins, it’s entertainment,” Betty said.  “None of this is real.”

“Then why is the CDC issuing videos to train medical personnel what to do during a zombie attack?”

“What?” asked Betty.  “Oh, for heaven’s – that’s not true.”

“Is so.  Look it up, it’s called Preparedness 101: Zombie Pandemic.  I’ll wait.”

Betty spoke the title and her computer brought up the Centers for Disease Control and Prevention.  She stared at the site offering the government-sponsored training to prepare for a zombie apocalypse and thought, ‘My tax money!’  “Beeky, that’s not real.  It’s a joke.”

“Your government spies on and renders its own citizens with impunity.  It does not joke,” Beeky said.  “And neither do I.  You know what this means.  It’s fact wrapped up to look like fiction to avoid panic.  Yet when the panic comes, they can claim they gave us all fair warning.”

Betty moaned.  “Okay, we have gotten far off the topic of isolating cells from urine and turning them into neurons.  Are you collaborating with the Chinese group?”

“Not yet, I need to develop a serious proposal and line up some serious funding commitments.  Think about it.  All those neurodegenerative diseases together are a small patient population.  Zombies affect us all, the whole seven billion people’s worth.”

“What will you use as the poison?” Betty asked.  “Since zombies are already dead, what harm could poison do to them?  How will you conduct the trials to demonstrate efficacy?  Do zombies need to sign informed consent forms?”

There was silence from Beeky.  Followed by more silence.  Then he uttered something more fowl than birdlike.  “Okay, okay,” he said finally.  “I’ll focus on feeding your very own zombie army.  Keeps the bad guys out of your yard.”

“Stick to those neurons and their medical uses,” Betty said.  “Diseases like Parkinson’s need better options.  Leave the zombies to Hollywood.”  She pulled a kitchen timer off her desk and set it to one second.  When the alarm went off, she said, “Oh, sorry, I need to go now.  Good luck, Beeky.”  She broke the connection quickly to avoid any awkward pleadings and goodbyes.

After a pause, Betty called another number.  A voice said, “Cappuccino Pharmaceuticals, this is Rupert Madasheck.”

“Really?  Are you mad as all that?”

“Betty, good to hear from you,” Rupert said.  “How are things going at BBB and B?”

“Stranger than you think,” Betty said.  She briefly described her conversation with Beekman and said, “I don’t think we will spend time trying to raise capital for him on this one.”

“Good plan,” said Rupert.  “Those urine cells were transplanted into rat brains.  Make sure you know those rats actually exist.”

“Of course they exist,” Betty said as she glanced at her monitor.  “I see at least one other paper published a year ago from the same group.”

“Well, not to be overly cautious or anything,” Rupert said, “but there was already a recent report of misconduct.  Apparently someone published work on cardiovascular disease in diabetic patients.  Important stuff, and there were about ten papers over the last decade, all using a strain of mouse that never existed.”

Betty gasped.  “Oh, Rupert!  That’s terrible.  It’s not anyone at Cappuccino, is it?”

“No, of course not.  It was some university guy.  Just not a smart thing to do.”  Rupert tapped on a keyboard, then said, “Oh, yes, opera night tonight.  Shall we meet at the Met?  According to the calendar, they are doing a special fundraising performance of Evenings in Quarantine: The Zombie Opera.”

Copyright ©2013 Bixogen, Inc. All rights reserved. Used by permission.  No part of this work may be reproduced or transmitted in any form or by any process without prior written permission.

Episode 23: What’s In a Name?

Rupert Madasheck was not the only CEO in the club’s cherrywood paneled room that day.  Gazing up into the distance at the crystal chandeliers, he eased himself into an overstuffed chair next to fellow CEO Gjioughneh Kqueuerillieux.  As he glanced around the room at the executives lounging at the Jonathan Club, Rupert asked Gjioughneh how things were going.

“Terrible,” Gjioughneh said.  “We were just informed that the PMA for our OctoPlex gel was rejected.”  Gjioughneh stared down at his folded hands and sighed.  “I just don’t understand it.  You can’t ask for better clinical trial outcomes.   It’s been on the market outside the US for a decade.  The manufacturing profile is top notch.  What else do they want?”  His fingers gnarled around each other in a knot.

“What exactly does this, um, this Octomom do?” Rupert asked.

“OctoPlex, not Octomom,” Gjioughneh said without looking up.  “It lessens the pain from failed surgery, particularly botched jobs to relieve Restless Third Leg Syndrome.”

“Oh, yes,” said Rupert.  “The syndrome that’s not just for congressmen anymore.  There’s surgery for that?”

“As a last resort,” Gjioughneh said.  “The drugs available for it just can’t stop all the scandals, so people need to take drastic surgical measures.  But surgery has a lot of problems and high chance of lifelong pain.  Too bad there’s a political angle.”

At the word ‘political,’ Rupert hunched his shoulders as if leaning into a rainstorm.   He remembered the never-ending stream of politicians sending lewd photos of themselves to would-be mistresses.  “Don’t tell me Congress wants your gel all to themselves.”

“No, it’s worse.  Congress wants to save money by cutting funding to the FDA.  So they are retaliating to make the House of Reprehensibles feel the pain.  We really believe the rejection is bull,” Gjioughneh said. “I’ve decided we’ll file a petition for reconsideration.”

Rupert looked up with a startled expression.  “You could do that?  Won’t it just annoy them?”

“We’re going with the ‘creates jobs in the US’ angle.  Once we get approval we can put a dent in the unemployment rate.”  Gjioughneh’s eyes glazed suddenly in rapt attention and he pulled out his vibrating YouPhone.  After fumbling for a second, he held it to his ear and said, “Gjioughneh here.”

Knowing that cell phone use is frowned upon at the Jonathan Club, Rupert looked away and twiddled his thumbs patiently while Gjioughneh listened to his call.  Should he edge away and leave Gjioughneh in peace?  Should he pull his own phone out for a quick game of Sudoku while pretending to work?  Would Gjioughneh be escorted to the floor with the phone booths?  Before Rupert could decide, Gjioughneh put the phone down.

“Rupert, I want to get out of this business,” Gjioughneh said.  “Turns out the FDA denial was based on the fact that no one at FDA could figure out how to pronounce the name of our company.”

Rupert’s eyebrows shot up.  “They couldn’t pronounce ‘FzGnque’ so they rejected Octomom?  I can’t believe that.”

“OctoPlex.”  Gjioughneh shook his head sadly.  “You’re close.  It’s pronounced ‘FzGnque.’  But it’s true.  They were too embarrassed to contact us.”  He frowned and looked around the room.  “We can change our name to FrzeuQ if they want.  And who are they to complain anyway?” he added.  “Is it ‘FDA’ or the FDA?”

Yes, this story was inspired by an actual news article.  Brownie points for finding the original source! –      The BixoBrat

Copyright ©2013 Bixogen, Inc. All rights reserved. Used by permission.  No part of this work may be reproduced or transmitted in any form or by any process without prior written permission.

Just a Passing Phage

by the BixoBrat

“No, but I can pay with my Bitcoin account,” Rupert said.

The hospital receptionist smiled for the first time. “That trumps insurance,” she said. “Go right down this hall, third door on the left.” Rupert barely heard over the screaming of infants and moaning of victims in the packed waiting room.

“Why didn’t I think of that two hours ago?” Rupert thought as he strode out of the waiting room. A heavy cough turned the stride into a hobble, and bounced him against the wall. A mule train of coughs poured out of his lungs. Hunched over, he fumbled and clutched for a doorknob. “Did I make it to door number three?” he thought as it opened. One last cough flung him inside and he sprawled across a bed just inside the doorway.

A perky young woman’s voice near his ear said, “Our first experiment shows up just in time.” Rupert moaned, rolled over, and looked up at a thin smiling woman in a lab coat who sat next to the bed. She said, “Time to give him the shotgun phages.”

A voice across the bed and out of Rupert’s field of vision laughed. “No, you just had the last patient. This one gets my nanobot.”

The young woman looked down at Rupert and said, “Too bad if you let this engineer at you. I could have saved your life. My phages are viruses that infect and kill every bacterium you could have. His little robots will just prolong your pain.”

The engineer said, “Not to worry, mister, I have a nanobot that will find and identify the bacterium, and kill that one type specifically. You’re as good as cured already.”

“What if he’s co-infected with several bacteria simultaneously?” the young woman asked.

The engineer repeated her words in a whiny high-pitched voice. “The nanobot stays on the job until they’re all cured.”

“It’s a virus,” Rupert says.

“What?” they both ask. “Like, how would you know?”

Rupert winced and said, “I know because I’ve taken every antibiotic on the shelf.”

The two lab coats looked at each other for a second, then burst out laughing. “Those old wives’ tales? They don’t work, never did.”

“Weird, my grandmother swears by them,” the engineer said. “Said it cured just about anything. Except cancer.”

“Except HIV. And we have mutant tuberculosis to cure lung cancer now,” the young woman said. “So what happened forty years ago? Did bugs get resistant, or did they stop making antibiotics when they fell off patent? Which happened first?”

The young man waved his fingers and clawed at the air. “I know,” he said. “Some sick genius let loose a mutant. Put it in the water supply and everybody died. You might have missed that story.” Rupert winced as the youngsters laughed.

Rupert squinted at the young woman and read “Grozny” on her lab coat. “Dr. Grozny, could I ask you something?”

She grinned shyly and said, “Susie. I’m not a Ph.D. yet, just a grad student. Jeremy and I might graduate about the same year soon.”

“Another two or three years oughta do it,” Jeremy said.

“You’re not even doctors?” Rupert asked. “I don’t even rate a real doctor?”

“Oh, no, they’re busy writing grants,” Jeremy said. “And the postdocs are monitoring hospital programs like this one.”

“Or do you mean an M.D.?” Susie asked. “They work on surgery, they don’t bother with the simple stuff like infectious diseases. A few rounds of treatment and you’re cured. That’s great for a graduate thesis, but the field changes so fast that they can’t teach anything in med school.”

Rupert thought, “I must call Betty again. Why doesn’t she answer?” He flicked his tongue over the GoldTooth and heard Betty’s phone ring. And ring.
________
Dr. Slaughter Enjoys Her Gig
I walked the familiar route from the secured parking lot into the hospital through my personal underground tunnel. I had a surgery scheduled in an hour for a Point-oh-one percenter, but first I had a consultation booked with a Point-oh-oh-one.

I went to my favorite consultation room and set the Sight/Sound for waterfall mood music and a flowing stream projected on the floor. I dialed up a faint mist of clary sage and coriander to reduce stress. Ms. Hamdan, the Point-oh-oh-one percent patient, arrived and eased back in the reclining chair.

She told me she would not let a doctor in her country go poking around there, pointing below her abdomen. I told her this was routine, not any medical urgency involved. I said it nicely, since I was glad to get an ‘Oh-oh-one. I hated being crassly commercial but I knew the more zeros a patient has, the better chance of moving from their Bitcoin account to mine.

Ms. Hamdan told me my touch was so gentle she wouldn’t dream of going to anyone else, even if that meant I had no time to waste on any One Percenters. I sighed and admitted I no longer even had time to see any Point-Ones.

Soon enough, a bell chimed to indicate it was time for the scheduled surgery. I excused myself and left Ms. Hamdan to the mercy of the interns. I regretted spending so much time on a single Point-oh-oh-one, and vowed to cut the time to nine minutes max. I headed down my private corridor to the Fine Control Operating Room, and sat down in my favorite Fanatic Voyager chair. Technicians wordlessly attached the wired gloves to my hands. I watched the hologram cube in front of me until the patient’s outline appeared. I had no idea where the patient was physically, but the complete 3D image lay before me. With a tap of my feet on the chair pedals, I rotated the image to view the arterial occlusion.

I remarked to the techs how my grandmother had made do with the old fiber optic shape sensing and localization to track positions of the surgical tools inside the patient. I saw how they rolled their eyes as if I said that every time I came in to guide surgery. As my gloved fingers remotely manipulated the laser scalpel with its flexible whisker wire, I thought of Grandma and her primitive sensors on guide wires and catheters inside the patient for as long as three hours. My pinkie eased the flexible catheter down the artery as it stretched around intervening organs. I zeroed in on the occlusion and thought how far minimally invasive surgery had gone. I vaporized the occluding plaque without allowing it to dislodge. I retracted the flexible catheter and laser scalpel, each much thinner than a hair. I shuddered as I recalled the old cardiac catheters in the Mayo Museum, huge pipes up to 3 millimeters in diameter.

Sighing deeply, I thought that the surgery went smoothly without complications, as per our standard policy so my job was complete here. I eased my hands out of the wired gloves, wrote another tic mark on the chair with a marking pen, and stood up. After a total of five minutes, I stepped out of the Fine Control OR and wondered if I could have finished in four minutes. I hurried down the hall to my next appointment, that poor woman Betty Something who was hit by a falling piano. I knew Betty had so many zeros after the decimal that she rated a personal post-operation visit.
________
Betty in Her World of Hurt
Betty struggled to consciousness in a hospital bed somewhere, surrounded by confused visions. “I am Betty, hear me roar,” she thought but could not say. A perky nurse announced, “We must perform some Tests!” Betty’s ex-boyfriend from high school swam into view, with a large object just behind his ear. “You didn’t die of brain cancer after all!” Betty shouted telepathically. “Of course not,” he said, “and this magnet on my head keeps me alive and tells me what to do.”

“The Phase III drug trial is going well!” announced a suddenly appearing Rupert. “Tests!” said the perky nurse, holding out a urine collection cup. “How is the trial going?” Rupert asked. Betty faded away into oblivion.

Betty was awakened by the perky nurse, who promptly began drawing blood samples. “The hospital conducted several tests on you already prior to admitting you,” the nurse explained, “not just for MRSA but pneumonia and every infectious disease known. I’m sure we will give you a clean bill of health — and a bill for it all. You’ve already paid an arm and a leg. Tee hee.”

Betty found she could not move her left arm — or her leg. “What happened to me?” she asked.

“Whatever it was, it’s not the hospital’s fault!” said the perky nurse. “I think the ambulance report said you were hit by a falling
piano while shopping on Fifth Avenue.”

Betty gasped and sank back into the arms of Morpheus who treated her more gently. His arms of soft foam caressed her side and shoulder. He reached carefully to her knee and gently prodded. Wordlessly, he spun a gossamer web of comfort. Betty felt the pain and ache leach out of her. She reached her arms out and hugged her knees, then stretched full-length. Morpheus gave one last soft caress of her cheek and quietly ebbed away.

“Well, and how are we this evening – er, morning?” It took Betty a while to register that the voice came from a chrome box covered with flashing lights. “You would be Betty? You are our bionic patient, yes? I’m Dr. Patel, your roboteledoc.”
“What’s a roboteled . . .” Betty’s voice trailed off as she caught the implication. Dr. Patel was in India and visiting her bedside remotely.

A light on the box brightened, then dimmed. “Now while I think of it,” Patel’s roboteledoc said, “I’d like to prescribe some Botox. That should clear up all that severe underarm sweating.” Betty turned crimson with embarrassment. “And it should take care of that nasty cervical dystonia of yours.”

“But I don’t have any – ” Betty’s protest was cut off abruptly by a high-pitched screech from the roboteledoc.

“I don’t have time for uncooperative patients,” Patel roared in an overamplified voice. “Good thing this box has an amp left over from old heavy metal shows.” The windows behind Betty shattered from the noise. “Now we all know that cervical dystonia has chronically been underdiagnosed. Good thing I recognized the insidious symptoms. And there are positive side effects: it will cure headache, pain, spasticity and juvenile cerebral palsy.”

“What?” Betty gasped. “How could I have juvenile -?”

“Tut tut,” said the roaring robot, “you can never be too careful.”

“Just so,” Betty said as anger flowed out to her fingertips. “I’ll have my lawyers look into this! I’m sure I recall the Justice Department cracking down on this off-label Botox use decades ago.”

“Ah, you Americans have such a problem,” the Doc-in-a-Box said. “This is no problem here so as your doctor I say it’s OK.”

Betty flicked her tongue to trigger the GoldTooth and said, “Rupert? I need our legal staff.” The roboteledoc lights flicked off.

An hour later, Betty flicked off the connection to Rupert and pondered. She needed a good crossword puzzle to take her mind off of things. “How can anyone help Rupert?” she thought. “Who bothers with infectious diseases any more?” To the left of the bed was a nightstand with bottles of seltzer water and an issue of “More Puzzles That Humans Can’t Solve.” She reached over for it, and found a pen tucked into the pages. As she lifted the puzzle book, she noticed a strange crawling sensation running up and down her arm.
The door opened and someone in a lab coat walked in. Betty pondered a puzzle clue and looked up. “Yes, nurse?” she asked as she read ‘J.O. Slaughter’ stitched onto the lab coat.

The visitor stiffened visibly and said, “Doctor. I am not a nurse.” The last word sounded more like a sneeze than a word.

“My apologies,” Betty said. “Doctor. To what do I owe the pleasure?”

“I am your surgeon,” Dr. Slaughter said. “I performed the surgery to connect your prosthetic limbs.”

Betty looked at her arms. “Surgery?” she asked. “What surgery?” Her arms both looked perfectly normal. The crawling itch erupted in her left arm and she sucked in her breath sharply. “Is that why it feels there are worms crawling around inside my arm?” She flailed her arm and then scratched at it.

“Stop that,” Dr. Slaughter said. “You most certainly do not have Morgellons Disease. Those are the nanobots completing the job of connecting capillaries and rewiring your nerves. When you arrived there was nothing left of your left arm or leg, so we started from scratch.”

Betty looked at her left arm again. She tried to sort through the fragmented images of recent memory, but could not connect the pieces with Dr. Slaughter’s abrupt announcement. “You aren’t well practiced in the art of bedside manner, are you, Doctor?”

Dr. Slaughter sighed, shifted her weight awkwardly, and said, “I do very well in my consultations, thank you.” She fidgeted with hands in pockets. “I’m. I. I am not used to seeing patients actually ill.” She looked up quickly. “Oh. Or recovering,” she said. “I have never visited a recovering patient before. I find it fascinating. You did not even realize that you have a new arm and a bionic leg.”

“So I’ll need to learn how to walk again?” Betty asked. She remembered using her left hand to pick up the puzzle book.

“Do you think surgery is still done like it was fifty years ago?” Dr. Slaughter asked. “You can go run a Marathon tomorrow if you want. But first, wait for the nanobots to finish connecting your leg.”

Betty’s left leg began to itch. “Must not think of little buggie monsters crawling up my leg,” she thought. Her mind raced over the hour-long talk with Rupert. “Doctor,” she said. “Is it true you have no Infectious Disease department any more?”

Dr. Slaughter put her hands on her hips. “Nonsense,” she said. “We have the finest department on earth. Our tuberculosis clinic wrote the book on treating lung cancer with mutated TB.”

“What about bugs that only cause harm?” Betty asked. “The old-fashioned kind?”

“Oh, those old things.” Dr. Slaughter waved away the thought. “We have graduate students who work on those. No respectable pharmaceutical company will consider working on new treatments that cannot be financially viable. And all the old generics no longer seem to work.”

“Does every disease have its drug-resistant mutants?” Betty asked.

Dr. Slaughter pondered for a second. “Not my field. But as I recall, most antibiotics are now made in places with no regulatory oversight. They may have been selling sugar pills for the last twenty years. Why, do you feel sick?” She pulled a clipboard from the wall and peered at it. “It looks like you were tested for every possible infection.”

“It’s not me, it’s Rupert,” Betty said. “He is somewhere in the hospital trapped in experiments by some graduate students.” Betty closed her eyes and inhaled. “They aren’t even real doctors.”

“Oh, but they will be some day,” Dr. Slaughter said. “Do you want me to check in on them? Just let me know if it is an engineering department or the virologists.”

“Both,” Betty said. “They argue over what experiment to do as if he were a lab rat or, or, or someone on a GenRx policy.”

Dr. Slaughter sucked her breath in. “Generics Only? He may as well be de-” She stopped before saying the dreaded D-word.

Betty looked up with wide eyes. “No, certainly not. He has a Bitcoin account that mines itself. He can afford to fund this entire hospital. But …”

“Money, or even Bitcoin, can’t buy everything,” Dr. Slaughter said.
________
The Kids Have a Plan
“We got a call from some Dr. Slaughter,” Susie said as she helped Rupert sit up in bed. “Jeremy and I still aren’t sure how we want to treat you today. Either my shotgun phages or his latest nanobot. Or set up a whole new foundation with your name on it to sponsor a research program.”

Rupert coughed once. He coughed again. Then he coughed several times in rapid succession. He gasped for air and waited for his head to clear. “What’s that about a new foundation?” he asked.

“We’ll need financial support of course,” Susie said. “Once I wrap up my thesis on using phages to cure bacterial infections, I want to do a postdoc on developing virophages. You know, like, engineer a virus that destroys other viruses.

“Talk about wishful thinking,” said Jeremy the engineer. “We also need an approach that could actually work. My nanobots are a bit large to deal with viruses, so I’ll need a clean room facility to develop something smaller than nanobots. I call them femtobots.”

“I call them fembots,” Susie said.

Rupert scratched his chin. “Catchy name,” he said. He realized that his cough had faded into the background and his head cleared. “You two go get the paperwork to start this foundation and I’ll see what I can do.” He waved cheerfully as they left the room.

After they closed the door, he stood up and stretched. His tongue flicked the GoldTooth and he said, “Betty, I’m getting out of here now. And I promise I will never ever touch another one of George’s cheap cigars. Virus indeed, huh.”

Copyright ©2012 Bixogen, Inc. All rights reserved. Used by permission.  No part of this work may be reproduced or transmitted in any form or by any process without prior written permission.